Mohamed-Ali HAKIMI
🇩🇿 🇫🇷 scientist @Inserm - iab-grenoble.fr
👀 Host-Parasite Coevolution: The Toxoplasma Paradigm
ParaFrap deputy director - labex-parafrap.fr/en/
EMBO member - embo.org
🌍 pan-African idealist
#epigenetics #parasites
- “In the meantime, the world’s richest man (Musk) has been involved in the deaths of the world’s poorest children” www.theguardian.com/us-news/2025...
- Reposted by Mohamed-Ali HAKIMIAn ISWI-related chromatin remodeller regulates stage-specific gene expression in #Toxoplasma gondii. By Belen Pachano (ParaFrap PhD student) et al., team @hakimi.bsky.social. In @natmicrobiol.nature.com www.nature.com/articles/s41...
- Reposted by Mohamed-Ali HAKIMI🚨 Out now! Toxoplasma gondii ISWI remodeller TgSNF2h forms a complex that insulates active genes, regulates MORC-driven sexual commitment and ensures precise gene expression, safeguarding the parasite’s developmental program. #MicroSky 🦠 www.nature.com/articles/s41...
- Reposted by Mohamed-Ali HAKIMI
- Reposted by Mohamed-Ali HAKIMIThrilled to share my first paper, now out in @natmicrobiol.nature.com! Huge thanks to my amazing supervisor @hakimi.bsky.social and everyone who contributed to this work! www.nature.com/articles/s41...
- A humorous reflection on the first article from my stellar PhD student, Belen Pachano. communities.springernature.com/posts/open-s...
- In the silence of chromatin, Toxoplasma whispers change. TgSNF2h sculpts the genome - MORC in the backseat. Some genes wake. Others sleep. A dance of nucleosomes shaping space for life parasite stages to unfold. Now in Nature Microbiology: rdcu.be/ehkWp
- @inserm.fr presse.inserm.fr/cest-dans-la... Science must not be damaged, as it takes too long to repair.
- Huge congrats to colleagues & friends for uncovering PfSnf2L, the chromatin remodeler that Plasmodium relies on to shape its gene expression. A new inhibitor wrecks the blueprint, blocking parasite growth & transmission. Next up: Toxoplasma SNF2L/h—stay tuned! t.co/IqO4O3tWQX
- Reposted by Mohamed-Ali HAKIMIThrilled to announce the creation of the @elisabethbik.bsky.social Science Integrity Fund to provide "funding for training programs, grants, or awards for science integrity advocates." Thanks to @science.org for covering this. Help us grow the fund with a tax-deductible donation.
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- Hello everyone on Bluesky! 🧪 We are EMBO, the organization of more than 2,100 leading researchers that promotes excellence in #lifesciences in Europe and beyond. Read more: www.embo.org/about-embo/m...
- Reposted by Mohamed-Ali HAKIMISolving 25 years of frustration, Daniel Abbühl managed to tag trypanosome tubulin and to express it in an inducible manner, hence revealing flagellum assembly! A tour-de-force! Preprint here: www.biorxiv.org/content/10.1...
- Fungus fight just leveled up! @jeromegovin.bsky.social and coll. found a new way to take down drug-resistant Candida by targeting the Bdf1 bromodomain. 🦠🔥👏 Bravo for this epic study using epi-drugs !
- 🚀 Excited to share our latest research on antifungal drug discovery! 🍄💊 We use humanized Candida models and NanoBiT assays to identify selective inhibitors of the Bdf1 bromodomain, a promising antifungal target. doi.org/10.1002/advs... #AntifungalResearch #DrugDiscovery A 🧵 1/6 👇
- Bravo to the authors for this tour de force 🥳👏🏽
- Reposted by Mohamed-Ali HAKIMIOur assessment of a person's epigenetic ("biological") age has been centered on DNA methylation. A new report shows that a set of 7 histone markers has comparable accuracy and also uncovers new pathways of aging biology www.science.org/doi/10.1126/...
- Reposted by Mohamed-Ali HAKIMICuba’s Center for Genetic Engineering and Biotechnology has continued to shepherd the development of drugs and vaccines for cancer, infectious disease and other conditions and to date has obtained regulatory approvals in more than 50 countries go.nature.com/4gxkhYt rdcu.be/d4Z0N
- 👌🏽 perfect way to end 2024 👏🏽
- This work was a collaborative effort with the groups of @allshire-lab.bsky.social and @keithmatthews.bsky.social
- Reposted by Mohamed-Ali HAKIMI1/ We are excited to share our new paper in @jexpmed.bsky.social about humans with autosomal dominant IFNAR1 deficiency (doi.org/10.1084/jem....).
- what a 'tour de force' ! 👏🏽👏🏽 to the authors !
Ever wondered how transcription choreographs histone modifications? Our work reveals the basis of co-transcriptional H3K36me3 by SETD2. We visualize how a histone writer coordinates with the transcription machinery! This is the magnus opus of @jonmarkert.bsky.social! tinyurl.com/setd2
- Malaria – the world’s most deadly vector-borne disease – is particularly sensitive to variations in climate and weather. (...) Investment in climate-resilient health systems and paradigm-shifting new tools is critical to accelerate progress towards eradication. malariaatlas.org/project-reso...
- Reposted by Mohamed-Ali HAKIMIPlease join us Friday 12th at noon EST for Dr. @zamanian.bsky.social seminar at Parasite hour with #PeersInParasitology where he will share his recent work on new targets and strategies for helminth control. Need a zoom link? Register here: iu.zoom.us/webinar/regi....
- Reposted by Mohamed-Ali HAKIMIWe've been awarded a UKRI MRC grant to examine the causes and consequences of #heterochromatin hypomethylation in cancer 🥳. #postdoc opportunity coming in the near future. #epigenetics. Please share with anyone who might be interested.
- Great mentees make a proud PI.😊
- Day 2 ! With motivated students from @hakimi.bsky.social enthusiastically pitching their project !
- Apicomplexan parasites (#Toxoplasma #Plasmodium) showcase remarkable phenotypic plasticity and a compact genome. MORC might be the maestro, topologically orchestrating gene expression! 🎻
- Controlling the genes of a parasite. buff.ly/4g2ujRr
- Reposted by Mohamed-Ali HAKIMIPlease RS/RT. #GordonConference on "Histone and DNA Modifications" #epigenetics #chromatin 20-25. July 2025. Il Ciocco, Italy. Great speaker lineup. ➡️Register now www.grc.org/histone-and-...
- Real (Time) Tango of Transcription and Translation. 👏🏽👏🏽👏🏽 to Nusrat Shahin Qureshi & Olivier Duss 👇🏽
- First paper of our lab today @natureportfolio.bsky.social by Nussi! We provide a real-time movie on how #transcription and #translation cooperate using #single-molecule FM: we find long-range #ribosome/ RNAP communication mediated by #RNA looping! @embl.org #RNAbiology #RNASky t.co/a24Xxcxdo0
- A new 'crypto' story where the authors KO every single human gene to uncover #Cryptosporidium 's survival secrets. Dive into the preprint for the inside scoop ! 👏🏽👏🏽👏🏽Bravo to Bishara and colleagues for this new Opus from @saterialelab.bsky.social team. 👇🏽
- Have you ever wondered how knocking out every single gene in the human genome, one by one, might affect your intracellular pathogen of interest? We did, & boy was it a wild ride! Happy to share our preprint discovering the essential host genome for Cryptosporidium - www.biorxiv.org/content/10.1...
- Here comes the SUN1! ☀️ A bright discovery in parasite cell division! 👏🏽👏🏽👏🏽👇🏽
- Delighted to share our first manuscript on @bsky.app on a novel SUN1-ALLAN complex in Plasmodium MTOC and NE organization. Many thanks @zeeshanm.bsky.social; @eelcotromer.bsky.social; @ryanase.bsky.social ; Tony; Sarah; David F; Karine; Igor; Cyrille; Declan. Link: www.biorxiv.org/content/10.1...
- Exciting news! 🇫🇷 network ParaFrap is now on Bluesky! Calling all parasitologists (and beyond) to join us at 👉 @parafrap.bsky.social Let’s connect and share! 🦠 #Parasitology
- From my office window, a stunning sight: blue sky and snow-dusted mountains, the first of the season. #Grenoble
- Reposted by Mohamed-Ali HAKIMIOkay Bluesky people- there is now an account here for the British Society for Parasitology (BSP) at @bspparasitology.bsky.social!! BSP also has a Facebook group, LinkedIn (private group), X (for the moment), and a webpage at bsp.uk.net/Home! We have so many updates to come- #BSP2025 is coming! 🦠
- Honored and excited to be joining the EMBO young investigator community, alongside many admired colleagues @gautamdey.bsky.social @johandecelle.bsky.social and others I'm looking forward to getting to know! www.embo.org/press-releas...
- Reposted by Mohamed-Ali HAKIMIThe 2nd edition of the Paris-Munich Epigenetics meeting will be held April 9-11, 2025 in Paris. Attendance is free of charge. Please visit the website www.sfb1064.med.uni-muenchen.de/paris_munich... to find out more about the program and to register. #epigenetics
- Reposted by Mohamed-Ali HAKIMI🚨New COMMENT in Nature Microbiology: Microbial solutions must be deployed against climate catastrophe🚨 @gilbertjacka.bsky.social www.nature.com/articles/s41...
- Reposted by Mohamed-Ali HAKIMII just re-read this beautiful story by @pauligroup.bsky.social Just to enjoy how AI and alphafold revolutionize mechanistic research. 🤩 www.nature.com/articles/d41... www.cell.com/cell/fulltex...
- Toxoplasma did it again 👇🏽
- Reposted by Mohamed-Ali HAKIMIHow come we know so little about a protein that is the basis for the currently available malaria vaccines? New review on the Plasmodium circumsporozoite protein, with Photini Sinnis and Mirko Singer out now: authors.elsevier.com/c/1k7sK5Eb1x...
- Reposted by Mohamed-Ali HAKIMIWe have two open PhD positions in my group at @crg.eu. We are seeking candidates with a background in computational and/or molecular biology, and with a broad interest in evolutionary biology, gene regulation, and comparative genomics. 📅Apply before January 12 here: www.crg.eu/en/content/t...
- Post a non-religious photo you think as holy
- Reposted by Mohamed-Ali HAKIMIHappy Evolution Day! Today's the 165 anniversary of the initial publication of Charles Darwin's "On the Origin of Species" - and this is a page from his notebooks. 🧪
- Reposted by Mohamed-Ali HAKIMI@embl.org is searching for a "highly experienced, inspirational and dynamic leader" to serve as its new director general. Who do we wish to see at this position?
- CRISPR 🧬 vs CRYPTO 🦠: Bye-bye, parasite secrets! 👏🏽👇🏽
- Cryptosporidium is an important public health threat, and it deserves better genetic tools to study it! Here we’ve developed a targeted in vivo CRISPR genetic screen to identify parasite genes required for survival and virulence… www.biorxiv.org/content/10.1...
- go.bsky.app/7Zt4maR welcome to @omarharb.bsky.social @atheaslip.bsky.social @apicolipid.bsky.social @garrizabalaga.bsky.social To all colleagues I may have overlooked, feel free to ask to be added.at://did:plc:3tysqbxo6s5iwf4bxpncmiz5/app.bsky.graph.starterpack/3lb5g7ywpj22c
- Reposted by Mohamed-Ali HAKIMITrying to launch a Starter Pack on French Epigenetics. Message me to be included. Any ideas very welcome! go.bsky.app/2P2bJxsat://did:plc:ooc64a2a5bpn6gruf6lystzo/app.bsky.graph.starterpack/3lbewqqxkri2i
- Small (yet expanded) contribution. ☺️ bravo 🎉🎊🍾
- 🚨🚨🚨paper alert!!!!! Finally out!! Our small contribution to the trypanosomatids field! Using UExM we explored the journey of Trypansoma cruzi inside the host cell mdpi.com/2076-0817/13/1… @carlos_robello @paraymicologia
- go.bsky.app/7Zt4maR I'm sure I've forgotten some colleagues... speak up, and I'll include you in this ToxoCat group!at://did:plc:3tysqbxo6s5iwf4bxpncmiz5/app.bsky.graph.starterpack/3lb5g7ywpj22c
- Reposted by Mohamed-Ali HAKIMIPlease see our paper in Nature on read-write mechanisms of H2AK119 ubiquitination by Polycomb repressive complex I. Congrats to the whole team, especially Victoria and huge thanks to our collaborator JP Armache! Also big thanks to Mark Foundation for Cancer Research for the support! rdcu.be/dZ5HZ
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- #ProtistsOnSky Insanely PROUD to share our new collaborative project with @gautamdey.bsky.social & @centriolelab.bsky.social #PlanExM We think (almost certain) #Expansion #Microscopy (#UExM) is a turning point for #Protistology and #Cell Biology. Link: www.biorxiv.org/content/10.1...
- Reposted by Mohamed-Ali HAKIMIThe peer-reviewed version of our paper is out! Thanks to all co-authors, editor and reviewers for the smooth process 🤓🎉 And don’t miss the chromatin haiku! www.cell.com/molecular-ce...
- Do you want to know what happens when cells stop assembling chromatin during DNA replication? Check out the latest pre-print from our lab! True team work with many essential collaborators.. feedback welcome! www.biorxiv.org/content/10.1...
- Reposted by Mohamed-Ali HAKIMIScience ouverte et données de la recherche en bibliothèque: Comprendre les enjeux de la Science ouverte
- A great line-up of parasitologists ready to Rumble in the Bluesky Jungle!
- Trying to find my way around here. Have created a starter pack for parasitologists. Join, connect and spread the word! go.bsky.app/5UiPsYr
- Amazing PI based in the vibrant city of Lisbon (#Lisboa), leading groundbreaking research. Don’t miss this opportunity—apply now!
- @ERC funded postdoc position in our lab! We are looking for an enthusiastic recent, or soon to be, PhD holder to join our team to study atypical parasite kinases and how they contribute to severe human Malaria. long-term funding gimm.pt/jobs/postdoc... www.treecklab.org
- Reposted by Mohamed-Ali HAKIMIReminder for newcomers that bioRxiv has Bluesky accounts in every subject category - great way to keep up (please re-skeet) connect.biorxiv.org/news/2023/09...
- Reposted by Mohamed-Ali HAKIMICan colleagues amplify this appeal to journals and journal editors to open accounts on Bluesky, please? @MicrobioSoc @TrendsMicrobiol @CellCellPress @JBacteriology @jbiolchem @Nature @ScienceMagazine @PNASNews @MolMicroEditors @NAR_Open @NatureMicrobiol @NatureComms @ASMicrobiology 🙏 🦠🧪🧫🧬
- Reposted by Mohamed-Ali HAKIMI#ProtistsOnSky Our latest #Ichthyosporean #EvoDevo story, led by M. Olivetta, C. Bhickta, N. Chiaruttini & in co. with @burnsajohn.bsky.social is finally out @natureportfolio.bsky.social nature.com/articles/s4158 A multicellular developmental program in a close animal relative
- Reposted by Mohamed-Ali HAKIMIThe precursors to multicellularity are derived from natural processes.🧪 freethoughtblogs.com/pharyngula/2...
- It's really sad, this closure of veupathdb.org by the NIH. It deprives thousands of parasitologists around the world... At a time when the world is questioning democracy, this illiberal act endangers global research on endemic and neglected diseases. www.science.org/content/arti...
- Reposted by Mohamed-Ali HAKIMI
- Reposted by Mohamed-Ali HAKIMIJOB ALERT! The Department of Natural History, NTNU University Museum is seeking an associate professor for a position in vertebrate evolutionary genomics. www.jobbnorge.no/en/available... 🌍🧪 #AcademicSky #HigherEd #WomeninSTEM #EcoECRcareer
- Reposted by Mohamed-Ali HAKIMIHere's an exciting job for the right person. Chance to join the senior staff at EMBO. Based in Heidelberg at the EMBO headquarters, it's a great organisation and a great place to work. www.embl.org/jobs/positio...
