Philippe Bastin's Lab
Research unit @Institut Pasteur & Inserm dealing with trypanosomes, cilia and flagella, tsetse flies, intraflagellar transport, imaging by light and electron microscopy,...
research.pasteur.fr/en/team/trypanosome…
- Reposted by Philippe Bastin's LabCheck out our latest issue to read a Q&A with @thibautbrunet.bsky.social, who studies the evolutionary origin of animal morphogenesis at the Institut Pasteur. www.cell.com/current-biol...
- Reposted by Philippe Bastin's LabPostdoc position in my lab: investigating how the microtubule motor protein dynein-2 works in cilia. Here's dynein-2 at work translocating microtubules - how is this activity regulated? How does dynein-2 malfunction in disease? Find out more and apply: my.corehr.com/pls/uoxrecru...
- Reposted by Philippe Bastin's LabExploring the chromatin proteome of Trypanosoma brucei repetitive elements (telomeres, centromeres, 70bp repeats, 177bp repeats) using TALEs. Another great collaboration with @allshire-lab.bsky.social www.biorxiv.org/cgi/content/...
- Reposted by Philippe Bastin's Lab🚨 New preprint alert! 🚨 We’ve uncovered a key player in malaria parasite cell division—meet PfAnchor, the first apicoplast-specific dynamin adaptor protein! Check the thread below 🧵for more details. #U_ExM #Malaria #Apicoplast www.biorxiv.org/content/10.1...
- Reposted by Philippe Bastin's LabExcited for an inspiring meeting in France 🇫🇷 on #cilia and #centrosomes! The German #cilia community is en route—let’s connect and share science!
- Reposted by Philippe Bastin's LabWe support the scientific community - basically we're the good publisher who gives back which is why you should submit papers to our journals rather than supporting share holders!
- Reposted by Philippe Bastin's Lab🔥 Open postdoc position in human inflammation-driven control of infection! 🔥 Join me at the University of Geneva, Switzerland this summer as I’m moving my Wellcome-funded research activity to the Department of Microbiology and Molecular Medicine! (1/5) Please share!
- Dear cilia researchers, join us in the heart of the beautiful Vosges mountains to share your latest findings! This year, partnership with @for5547.bsky.social and keynote lectures by @micromotility.bsky.social and @mick-lab.bsky.social Registration is now open www.cfc2025.conferences-pasteur.org
- Reposted by Philippe Bastin's Lab📣Thrilled to announce that the registration for the 8th annual Czech #Cilia #Meeting (17 June 2025, #Brno) is NOW OPEN: 🪧https://forms.gle/wkooViZtBGxvVASNA 👩🔬INVITED SPEAKER: Ruxandra Bachmann-Gagescu ⏱️Registration deadline: 17 May 2025
- Reposted by Philippe Bastin's LabDid you know… It’s free to publish in Journal of Cell Science – there are no submission charges, page charges or colour fees. We also plant a tree for every peer-reviewed article we publish🌳 For details, visit our website: journals.biologists.com/jcs/pages/re...
- Reposted by Philippe Bastin's LabTrois de nos plus grands scientifiques, Yasmine Belkaid (@pasteur.fr), Bana Jabri (@institutimagine.bsky.social) et Alain Puisieux (@institutcurie.bsky.social), prennent la parole pour appeler à des réponses courageuses des pouvoirs publics face aux attaques contre la recherche. ⬇️
- Reposted by Philippe Bastin's Lab🌍🔬 📣 Please spread the word! How can cell biology shape a more resilient planet? Virtual registration still open for @embo.org Workshop - Cells 4 Climate Resilience meetings.embo.org/event/25-cli... 🗓️ Deadline: April 11 🎥 Watch the teaser youtu.be/8eMJ91udHDs @cells4planethealth.bsky.social
- Reposted by Philippe Bastin's LabCreating an asymmetric heart: @tbonnely.bsky.social @audreydsg.bsky.social @meilhacsigolene.bsky.social &co identify Notch3 as a novel asymmetric factor in lateral plate mesoderm that acts as a genetic modifier of NODAL to regulate #heart #morphogenesis @plosbiology.org 🧪 plos.io/42q6H4L
- Reposted by Philippe Bastin's LabMalaria parasites are an extreme example of ribosome heterogeneity. But how do they control which ribosomal RNA to express when? Check out this mountain of work led by @ju-couble.bsky.social with @tizvignolini.bsky.social @jessmbryant.bsky.social www.biorxiv.org/content/10.1...
- Reposted by Philippe Bastin's LabGreat pitch for why to submit, review & write for @jcellsci.bsky.social by @drmichaelway.bsky.social - for the cell biology community, by the cell biology community💪! And great to see on screen the ECR best paper award launched in the late and much missed David Stephens’ name! #WeNeedMoreDavids
- Happy moments ahead of Mark Carrington special symposium tomorrow @uniofcam.bsky.social
- Reposted by Philippe Bastin's LabOut today: Exciting intermediate between endosymbiont and organelle identified! Endosymbionts in Angomonas deanei lost nearly all bacterial cell division genes. Instead, we identified a host-encoded protein, ETP9, that became specialized for endosymbiont division. 1/2 www.science.org/doi/10.1126/...
- Reposted by Philippe Bastin's LabNous avons aujourd’hui l’occasion unique de construire cette #Europe de demain que Stefan Zweig a tant regretté de ne jamais voir advenir. Une Europe qui ne soit pas seulement un marché, mais un véritable foyer intellectuel et scientifique... #esr
- Reposted by Philippe Bastin's LabNew great paper in Developemental Cell by Nathalie Delgehyr and collaborators in Nathalie Spassky's lab on the action of actin-based cytoskeleton on the the nucleus in multiciliated cell differentiation. #cilia www.sciencedirect.com/science/arti...
- Superb piece of work!
- I am super excited to share our latest work on the structures of doublet microtubules from trypanosomatid parasites, the causative agents of leishmaniasis, Chagas disease, and African sleeping sickness. tinyurl.com/48sh3xn5
- Reposted by Philippe Bastin's Lab🚨Job alert! Our IBEID partner Ivo Gomperts-Boneca is hiring a Project Manager to coordinate an #ERC synergy project AI4AMR 🦠 AI, deep learning & interdisciplinary science to accelerate the discovery of new #antibiotics against resistant #bacteria www.labexibeid.fr/offres-emplo... 📍@pasteur.fr
- Brilliant work with unprecedented level of resolution of the trypanosome axoneme!
- Trypanosome doublet microtubule structures reveal flagellum assembly and motility mechanisms | Science www.science.org/doi/10.1126/...
- Reposted by Philippe Bastin's LabThe symposium to celebrate Mark Carrington's career is coming soon. You have until 15th to book in. A great day of science, particularly if you are excited about kinetoplastids! And a day of celebration.
- Reposted by Philippe Bastin's LabSO MANY STAND UP FOR SCIENCE EVENTS TO CHOOSE FROM—153 and COUNTING! To get more information on our local events and to register your own, head to www.standupforscience2025.org/local-event-information/ ☀️⬇️🌎
- Reposted by Philippe Bastin's LabThe VEuPathDB survey asked users to estimate the impact on their lab's productivity (from 0-100) if VEuPathDB resources were to disappear altogether. We also asked them to describe the impact. ✏️The infographic lists a few key themes that emerged from nearly 1500 comments!
- Exciting opportunity!
- Re-posts appreciated! We have an open PhD position w/ Prof Harold Auradou on #microswimmers/#protists in complex media! Students get to spend at least 12 months in Paris, and will receive their PhD from both Exeter and Paris-Saclay! Apply by 31st Mar. More details: adum.fr/as/ed/voirpr...
- Cilia talking to each other! 🔊
- Last from the archives, scanning #electronmicroscopy pictures of #cilia in #kidney IMCD3 cells (no triton) by Rania and Thierry from @bastinlab.bsky.social. The longest straight cilium ever and two interacting ones!
- Reposted by Philippe Bastin's LabLa tribune du mouvement Stand Up for Science France parue ce matin dans Le Monde (texte complet et signataires en ALT). Mobilisons-nous le 7 mars pour défendre la recherche scientifique et l'université ! #StandUpforScience #StandUpforScienceFrance
- Thanks to a new mass spec pipeline for analysis of the #tubulin tail, the team of Julia Chamot-Rooke and Mariette Matondo revealed a few surprises for #trypanosome beta-tubulin: -a new glutamylation site -far less exhaustive detyrosination Preprint here: www.biorxiv.org/content/10.1...
- Stripping mammalian cells was an exciting experience 😉 Transition fibres are even visible on the right image!
- In 2009, Rania Ghossoub in my lab and Thierry Blisnick in @bastinlab.bsky.social decided to apply a protocol used in Trypanosoma to remove membranes and have access to the axoneme, here is what they saw in IMCD3… #cilia
- Reposted by Philippe Bastin's Lab#VeilleESR #ESR Le lancement de la mobilisation du 7 mars pour défendre les sciences et la démocratie contre l'obscurantisme et les extrême-droites a eu lieu cette nuit. L'effort fait par des composantes diverses de la communauté scientifique pour s'unir est incroyable. standupforscience.fr
- Reposted by Philippe Bastin's LabThanks Renata Basto and Journal of Cell Science for respectively writing and publishing this piece. There is now this very important worldwide initiative: standupforscience.fr l! 😃
- Reposted by Philippe Bastin's LabIn her Essay, Renata Basto highlights the huge budget cuts facing the scientific community in France. In response to the cuts, a group of researchers has formed the ‘Pour une Recherche d'Avenir’ initiative to secure the future of French research. journals.biologists.com/jcs/article/...
- Reposted by Philippe Bastin's Lab📅 Save the Date! The EMBO Workshop "Host-Parasite Relationship: From Mechanisms to Control Strategies" organized by @ParaFrap will take place on October 5-8, 2025, at Les Embiez Island. Stay updated on registration opening —enter your email here: coming-soon.embo.org/w25-83 #Science #Parasite
- Reposted by Philippe Bastin's LabCome join us in Copenhagen! There is still time to apply for the 2 vacant PhD positions available in our group -for more info see below #cilia
- Reposted by Philippe Bastin's LabSeminar on March 6 at noon: Timothy Wai (@pasteur.fr , Paris) will talk about #Mitochondrial membrane dysfunction and cardiac #inflammation institutcochin.fr/en/agenda/mi... @upcite.bsky.social @cnrsbiologie.bsky.social @inserm.fr
- Great opportunity to join a fantastic lab with one of the most creative PIs!
- Looking forward to know more about the amazing choanoflagellates!
- Excited to announce the 10th "Choanoflagellates & Friends Workshop" over May 20-22 in our own Institut Pasteur in Paris: 2025choanocon.wordpress.com Registrations open til March 15, abstract til March 5. Pre-conference event for students/postdocs on 19/05. Plenty of slots for selected talks/posters!
- A video clip to see #trypanosomes in #3D #FIB-SEM Many thanks to Valérie Zeitoun and Jeanne Fenouil for their patience during the recording and to Adeline Mallet and Manu Majrouh at the UBI of @pasteur.fr www.pasteur.fr/fr/journal-r...
- I forgot to say that the tagged tubulin incorporates very well in the spindle, here after a 4-hour induction (green, magenta is axoneme + transition zone). However, we could not see a defined polarity, in contrast to flagellar or cortical microtubules.
- Solving 25 years of frustration, Daniel Abbühl managed to tag trypanosome tubulin and to express it in an inducible manner, hence revealing flagellum assembly! A tour-de-force! Preprint here: www.biorxiv.org/content/10.1...
- Reposted by Philippe Bastin's LabDid you know… It’s free to publish in JCS – there are no submission charges, membership fees, page charges, or colour charges. For details on this and other reasons to choose JCS, visit our website: journals.biologists.com/jcs/pages/re...
- Solving 25 years of frustration, Daniel Abbühl managed to tag trypanosome tubulin and to express it in an inducible manner, hence revealing flagellum assembly! A tour-de-force! Preprint here: www.biorxiv.org/content/10.1...
- Reposted by Philippe Bastin's Lab@ird-fr.bsky.social @dndi.org and Institut Pasteur de Guinée welcome the @who.int validation for the elimination of sleeping sickness in Guinea ↘️
- Great work showing that cilia are worth even more than motility! 👏👏👏
- 🚨New paper out!🚨 Excited to share our study published in Science Translational Medicine. This 5yr project was led by Susan @dutcherlab.bsky.social and Steve Brody. We asked a simple question: why do some PCD patients develop more severe lung disease than others? 1/ www.science.org/doi/10.1126/...
- Reposted by Philippe Bastin's Lab🧵 🙌🏾 Congratulations #Guinea for eliminating sleeping sickness (gambiense form) as a public health problem in the country! bit.ly/3Cgp0zq 1/3
- And was great with 9 talks and close to 100 participants!
- Better with the link 😅 @club-cfc.bsky.social
- Follow our French #cilia network! Only on BlueSky!
- Reposted by Philippe Bastin's Lab🌍 "Le vivant est la nouvelle frontière." ✨ Découvrez le plan stratégique "Pasteur 2030" et la vision de l’Institut Pasteur pour une science au service de la santé humaine. #Pasteur2030
- Great talk of Christine at the #cilia symposium @institutimagine.bsky.social today! proud PI! Many thanks to @alexbnmrh.bsky.social for the organisation!
- Reposted by Philippe Bastin's LabThe MPM XXXVI page is now live. Sept 14th to Sept 18th. More updates will be coming soon. Check it out on the parasitesrule.com website. Organized this year by Richarch McCulloch @rmc9z.bsky.social, Photini Sinnis, Marc-Jan Gubbels, Deepali Ravel & Omar Harb @omarharb.bsky.social
- Reposted by Philippe Bastin's Lab👀 Looking for a PhD position but you are torn between cilia biology and computational AI research? 😜 The Cilia-AI Doctoral Network has you covered! Lots of fantastic projects throughout Europe, also @humantechnopole.bsky.social with us or @gaiapigino.bsky.social - apply now! ‼️ www.cilia-ai.eu
- Reposted by Philippe Bastin's LabAre you interested in #trypanosomes #biomolecularcondensates and/or #geneexpression? We are looking for a highly motivated postdoc to work with with us in the beautiful city of York! Please share! jobs.york.ac.uk/vacancy/post...
- Come and celebrate the exceptional career of Mark Carrington (24th March at University of Cambridge)!
- 🚨 Retirement Symposium for Prof Mark Carrington of the University of Cambridge Our #Trypanosoma colleagues may want to attend this symposium in Cambridge on the 𝟐𝟒𝐭𝐡 𝐨𝐟 𝐌𝐚𝐫𝐜𝐡, 2025 (register by the 15th!) - Details at QR code & tinyurl.com/2uw8tryu
- Brilliant work of Maude Leveque with @mila-montpellier.bsky.social Jeremy Vincent among others revealing unexpected features of #tubulin detyrosination in Leishmania, especially in the amastigote stage!
- Pasteur is on Bluesky! 😀
- Reposted by Philippe Bastin's LabHave you finished your #PhD and are interested in exploring how #parasites cross the vasculature to colonize tissues? Do you fancy catching some #waves in the Atlantic? Or eating grilled fish by the beach? Join us in #Lisbon at GIMM, where science meets quality of life. @parasitesrule.bsky.social
- Reposted by Philippe Bastin's Lab💼 Two funded PostDoc positions (3 years) on Trypanosoma brucei and its interactions with blood vessels | Lisbon, Portugal | Labs: @luisamfigueiredo.bsky.social #GIMM and Cláudio Franco #BCR 🔬 #Parasite - vasculature interactions 🗓️ Start: by June 2025 🔗 Details: labex-parafrap.fr/en/job-offers
- Exciting programme for webinars in parasitology next year, including @pasteur.fr colleagues Gretchen Diffendall (Artur Scherf's lab), Brice Rotureau, Karinna Rubio (Lucy Glover's lab) and Chetan Chitnis, stay tuned!
- We are pleased to announce the ParaFrap Webinar program for 2025. Join us labex-parafrap.fr/en/conferenc... The ParaFrap network wishes you a happy holiday season.
- How do #trypanosomes restrict #IFT to only 4 doublet microtubules? Two hypotheses were proposed (restriction @ the flagellum base or @ the injection) but in this preprint, Aline Alves reveals it is a third way! It all happens in the proximal portion of the flagellum! www.biorxiv.org/content/10.1...
- Inspiring discussions with paralympic athletes Mathieu Thomas, Esteban Herrault, Nantenin Keita and Tresor Makunda @pasteur.fr, raising fascinating parallelisms with the challenges we are facing as scientists
- Exciting PhD project in the lab of Sue Vaughan at #Oxford Brookes University to study #trypanosome basal bodies and flagellum formation www.jobs.ac.uk/job/DKY713/n...
- Congratulations to Jean Marc @tsagmoj.bsky.social who won an Early Career Entomologist Award from the @royentsoc.bsky.social for his PhD work on tsetse fly midgut composition and its possible impact on #trypanosome transmission! 💪 Read more here: www.royensoc.co.uk/res-journal-...
