Pauli Group (posts by Andi Pauli)
Exploring the mysteries of how life starts - from fertilization to dormancy; combining in vivo & in vitro (fish, mouse, cell culture, biochem); privileged to work with an amazing team @IMP!
paulilab.org
imp.ac.at/groups/andrea-pauli/
- Become our neighbor!! Check out this amazing opportunity @imbavienna.bsky.social - top-notch research environment with fantastic facilities, and all of that in a thriving international environment in beautiful Vienna!
- A big round of 👏👏👏 to our postdoc @idajentoft.bsky.social for being awarded a @hfspo.bsky.social postdoctoral fellowship for her research on #killifish #diapause in our lab! Welcome to the fantastic #HFSP community, Ida!
- 🎉Congratulations to our @idajentoft.bsky.social, postdoc in the @pauligroup.bsky.social on being awarded a HFSP fellowship! The funding will support her research into the molecular mechanisms that regulate translation during embryonic diapause. More about the project: www.imp.ac.at/news/article...
- Last days to get your registration and abstracts submitted for the @embo.org meeting on "RNA meetings Protein Decay" in Vienna (11-14 May 2025). Deadline to register and submit abstracts is April 1st!
- One week left to register and submit abstracts for being considered for talks at our upcoming #EMBO Meeting "RNA Meets Protein Degradation" in Vienna! Check out the program with a fantastic line-up of speakers, including keynotes by Rachel Green and Manu Hedge. meetings.embo.org/event/25-rna...
- If you want to listen to our fertilization story in Spanish for a change, here is your chance: Log-in to @vdeneke.bsky.social's online seminar next week!
- 📣Se viene otro gran #Reproseminar! Este lunes 31/3, tenemos el honor de recibir a la Dra. @vdeneke.bsky.social (@pauligroup.bsky.social @impvienna.bsky.social 🇦🇹) que presentará: 🧬"El comienzo de la vida: el rol de un complejo de fecundación conservado en vertebrados" 🕒15:00🇦🇷 |14:00🇺🇸EST Imperdible!
- Big congratulations to two really smart, kind & visionary young developmental biologists - Alex Schauer & Krista Gert - on securing prestigious @embo.org fellowships for their postdoctoral studies @mpi-cbg.de! A very special shout-out to our @pauligroup.bsky.social alumnus Krista!
- Postdoctoral researchers Alexandra Schauer in the @jesseveenvliet.bsky.social group at the @mpi-cbg.de and Krista Briedis Gert in the group of Claudia Gerri received EMBO postdoctoral fellowships for their research projects. Congratulations! 🎉 www.mpi-cbg.de/news-outreac...
- One week left to register and submit abstracts for being considered for talks at our upcoming #EMBO Meeting "RNA Meets Protein Degradation" in Vienna! Check out the program with a fantastic line-up of speakers, including keynotes by Rachel Green and Manu Hedge. meetings.embo.org/event/25-rna...
- Are you interested in supporting top-notch research in a collaborative research environment @impvienna.bsky.social in beautiful Vienna, Austria? Then this job might be interesting for you - we are looking for a Scientific Grant Writer! Please check out the ad for more details and how to apply.
- We are seeking to fill a type of position that will be new to the IMP: a Scientific Grant Writer to help with externally funded research projects throughout the process: identify donors, apply, coordinate collaborators, oversee implementation, & report back to donors. www.imp.ac.at/career/open-...
- A big shout-out for @dianapinheiro.bsky.social being featured as Woman in Science! A well-deserved honor for a fantastic scientist and inspiring mentor, and on top of that an amazing colleague and person. Super happy to have you as my office-neighbor and friend @impvienna.bsky.social!
- 🎉 Our @dianapinheiro.bsky.social is featured in a Women in Science book! The book, part of @cienciaviva.bsky.social's initiative, celebrates Portuguese women scientists. The latest volume launches tomorrow, #InternationalWomensDay, in Lisbon. 📖 Read more: imp.ac.at/news/article... #IWD2025
- Switching fields and/or wanting to become an expert in #zebrafish research? The @mblscience.bsky.social 2025 Zebrafish Development & Genetics course offers a fantastic opportunity to learn from leaders in the field! (New & final) Application deadline: March 28 www.mbl.edu/education/ad...
- Retrotransposon-derived capsids in the Dros. ovary revealed by CryoET! Amazing PhD work by @svenklumpe.bsky.social (still MPI Biochemistry) in collab with @juliusbrennecke.bsky.social lab - congrats to all authors! Really looking forward to exciting times with Sven @viennabiocenter.bsky.social!
- Happy to share our manuscript on the in situ visualization of the copia retrotransposon in its final form today published in @cellcellpress.bsky.social www.cell.com/cell/fulltex.... What’s new?
- Many US students don’t know how to seek opportunities outside the US. With some help from our colleagues in EU and Canada, we could put together a consolidated website of PhD opportunities and scholarships outside the US, organized by field. There might still be time for this year in some places.
- Our call to the international Vienna BioCenter PhD program just opened! training.vbc.ac.at/phd-program/ And if you are looking for postdoc opportunities, check out labs on our campus - there is amazing research in a wide variety of fields and topics going on! @vbcscitraining.bsky.social
- Big congratulations to Anais @aelewaut.bsky.social from Anna @obenaufa.bsky.social lab for this well-deserved award! I remember the beginning of your project in its early days of your PhD from your TAC meetings - amazing where you have taken it since!
- 🎉Congratulations to @aelewaut.bsky.social, recent PhD graduate from the @obenaufa.bsky.social’s lab, who won the Egon Macher Award for her research on how cancer evades the immune system! Read more: www.imp.ac.at/news/article... @viennabiocenter.bsky.social
- Congrats Gui from @dianapinheiro.bsky.social's lab for being awarded a Marie Curie postdoctoral fellowship! Excited to support on the medaka and hybrids part, and really excited to find out what you will discover!
- 🎉Congratulations to our Guilherme Ventura, postdoc in the lab of @dianapinheiro.bsky.social who secured a prestigious Marie Skłodowska-Curie fellowship! 🔬The funding will support his research on the mechanisms that control how the embryonic development clock is set: www.imp.ac.at/news/article...
- Big congrats @sebastianfalk.bsky.social - super happy to have you here as a fantastic colleague at the @viennabiocenter.bsky.social!
- Another tenured professor at the Perutz - congrats to @sebastianfalk.bsky.social! 👏 His lab, established in 2019, explores how small RNAs control gene expression through the RNA interference pathway 🔎 More ➡️ tinyurl.com/4c86dmr5 @univie.ac.at
- The @pauligroup.bsky.social fertilization team @vdeneke.bsky.social, @johannessuwita.bsky.social, Andreas Blaha & Karin Panser visiting Masahito Ikawa's lab in Osaka, Japan. Thank you to 'Team Masa' for the amazing hospitality, for joining for experiments and lots of memorable and fun moments!
- Switching fields to #zebrafish? Wanting to become an expert in zebrafish research? Check-out the @mblscience.bsky.social 2025 Zebrafish Development & Genetics course – a fantastic opportunity to learn from leaders in the field! Application deadline: March 13 www.mbl.edu/education/ad...
- Switching fields to #zebrafish? Wanting to become an expert in zebrafish research? Check-out the @mblscience.bsky.social 2025 Zebrafish Development & Genetics course – a fantastic opportunity to learn from leaders in the field! Application deadline: March 13 www.mbl.edu/education/ad...
- Vienna @viennabiocenter.bsky.social is indeed a fantastic place for life science and top-notch research where your ideas are more the limits than external factors!
- Out of the lab, into the wild: when @pauligroup.bsky.social's Andi Pauli puts on her @ox.ac.uk blue, you know it's business time! Austria's national broadcast ORF interviewed her on how #Vienna has become such an amazing place for life science research.
- Immensely proud of our Andreas (now Dr. Blaha!) for a brilliant PhD defense on the ‘Mechanistic Analysis of Sperm-Egg Interaction in Vertebrates’ - we'll miss you but wish you all the best! Thank you to the examiners Ori Avinoam, Bill Snell and Uli Technau for their time and insightful questions.
- Welcome on board @svenklumpe.bsky.social! Looking very much forward to have you as colleague @viennabiocenter.bsky.social - exciting times ahead!
- Thanks so much for the invitation to speak! I hope I sparked interest into some maybe less researched but by no means less interesting questions of egg dormancy, ribosomes & fertilization 😊! Thanks Alice Yuen for inviting me & everyone for the insightful questions - really enjoyed the discussion!
- Join us today for a talk of @pauligroup.bsky.social at 2:30 pm (UK time). Her talk will be about the fundamental principles during the egg-to-embryo transition. You can find the abstract on our website, and feel free to join our mailing list for access to the Zoom link.
- I can highly recommend the YEN 2025 meeting for students and postdocs working on 'anything embryo' - a fantastic meeting organized by students and postdocs for you!
- Registration open for this year's Young Embryologist Network meeting 19 May, The Francis Crick Institute, London thenode.biologists.com/yen-2025-con...
- Very interesting study by @madalenamrp.bsky.social @schierlab.bsky.social, using massive parallel reporter assays during zebrafish embryogenesis combined with deep learning to determine the impact of 5'UTRs on ribosome recruitment and protein output. Congrats to all authors!
- We (schierlab.bsky.social and Seelig lab) are very happy to share that our work has found a home at DevCell cellpress.bsky.social! Free access here: authors.elsevier.com/sd/article/S... What are the features in 5′ UTRs that determine when and how much of a protein to make during embryogenesis?
- Super happy that Clemens Plaschka will continue his exciting research direction with us at the @impvienna.bsky.social, and that we will keep him as a fantastic scientist and colleague - a win-win situation!
- Congratulations to Clemens Plaschka, who was promoted to Senior Group Leader at the IMP / Vienna BioCenter. We are thrilled and look forward to Clemens steering his research as part of our community for many more years to come! www.imp.ac.at/news/article...
- Last three days to apply to our international @vbcscitraining.bsky.social summer school and Talents-for-Future program in Vienna! If you are an international bachelor/master student who is excited about committing this summer to world-class research and gaining new experiences, then this is for you!
- The Vienna Biocenter Summer School 2025 call is now open for talented undergrads, it's a great prog. for students who are interested in the life sciences. training.vbc.ac.at/summer-school/ @impvienna.bsky.social @imbavienna.bsky.social @gmivienna.bsky.social @maxperutzlabs.bsky.social
- 'Making the sour sweet' - the magic Ledidi can do with genomics ML models! Great work by @jmschreiber91.bsky.social, and wonderful to make this freely available before 'pre-printing/journal publishing'!
- A year in the Pauli lab 'in pictures'. It's already a little tradition to look back at the many happy memories of the past year. Excited to see what 2025 will bring - may it be another happy, fun, successful and fulfilling year!
- A big round of applause 👏👏👏 to our postdoc Amy Nabih for securing an #EMBO postdoc fellowship! Amy will investigate how maternal age impacts embryo development, using zebrafish as a model system. Very curious to see what Amy will find out about this interesting new topic in our lab!
- 🎉Congratulations to our Amena Nabih, postdoc in the @pauligroup.bsky.social, who received an EMBO fellowship to study how maternal age influences embryo development! More about her project: imp.ac.at/news/article... @viennabiocenter.bsky.social
- The life of each of us began when a sperm and an egg came together. But what happens at a molecular level? Our latest work in Cell led by @vdeneke.bsky.social & Andreas Blaha reveals a conserved fertilization complex that bridges sperm and egg in vertebrates! (1/11) www.cell.com/cell/fulltex...
-
View full thread… as well as our external collaborators at the University of Toronto (Jeff Lee’s lab) and at the Hebrew University in Jerusalem (Joachim Surm @yehumoran.bsky.social)! (10/11)
- And last but not least, a big thank you to Victoria @vdeneke.bsky.social and Andreas Blaha for preparing this thread, and to Victoria for capturing this wonderful movie of fertilization in zebrafish in all its beauty that was selected as cover image of this Cell issue (thank you Cell!)! (11/11)
- A big thank you to everyone who supported and contributed to this work! It was an amazing team effort spearheaded by @vdeneke.bsky.social & Andreas Blaha with key contributions from Yonggang Lu from Masahito Ikawa’s lab at Osaka University,… (8/11)
- ...further members of the @pauligroup.bsky.social (e.g. @johannessuwita.bsky.social, Karin Panser, @claraphan.bsky.social), Alex Schleiffer, @86dominik.bsky.social & our amazing proteomics facility @elisabethroitinger.bsky.social @impvienna.bsky.social @imbavienna.bsky.social, ... (9/11)
- But what is this conserved sperm complex doing in fertilization? AlphaFold predicted the zebrafish trimer to interact with the egg factor Bouncer. Not only do we confirm this prediction, we find that complex formation is required for Bouncer binding! (6/11)
- Excitingly, this contrasts with mammals, where IZUMO1 interacts with JUNO, a evolutionarily and structurally unrelated protein to Bouncer. Our work presents an intriguing model of a conserved complex bridging sperm and egg through divergent egg factors in vertebrates (7/11)
- Together with Yonggang Lu in Masahito Ikawa’s group, we found that Tmem81 is essential for fertilization in zebrafish and mice (4/11)
- In line with the AlphaFold prediction, we show that Tmem81, Izumo1, and Spaca6 interact in zebrafish sperm and that the human orthologs interact in vitro (5/11)
- We ran all known fertilization factors in zebrafish against 1,400 testis proteins with the help of @86dominik.bsky.social (2/11)
- This screen predicted a conserved sperm complex of Izumo1, Spaca6, and a new related factor, Tmem81, which had been previously uncharacterized in fertilization (3/11)
- [Not loaded yet]
-
View full thread… as well as our external collaborators at the University of Toronto (Jeff Lee’s lab) and at the Hebrew University in Jerusalem (Joachim Surm @yehumoran.bsky.social)! (10/11)
- And last but not least, a big thank you to Victoria @vdeneke.bsky.social and Andreas Blaha for preparing this thread, and to Victoria for capturing this wonderful movie of fertilization in zebrafish in all its beauty that was selected as cover image of this Cell issue (thank you Cell!)! (11/11)
- A big thank you to everyone who supported and contributed to this work! It was an amazing team effort spearheaded by @vdeneke.bsky.social & Andreas Blaha with key contributions from Yonggang Lu from Masahito Ikawa’s lab at Osaka University,… (8/11)
- ...further members of the @pauligroup.bsky.social (e.g. @johannessuwita.bsky.social, Karin Panser, @claraphan.bsky.social), Alex Schleiffer, @86dominik.bsky.social & our amazing proteomics facility @elisabethroitinger.bsky.social @impvienna.bsky.social @imbavienna.bsky.social, ... (9/11)
- But what is this conserved sperm complex doing in fertilization? AlphaFold predicted the zebrafish trimer to interact with the egg factor Bouncer. Not only do we confirm this prediction, we find that complex formation is required for Bouncer binding! (6/11)
- Excitingly, this contrasts with mammals, where IZUMO1 interacts with JUNO, a evolutionarily and structurally unrelated protein to Bouncer. Our work presents an intriguing model of a conserved complex bridging sperm and egg through divergent egg factors in vertebrates (7/11)
- Together with Yonggang Lu in Masahito Ikawa’s group, we found that Tmem81 is essential for fertilization in zebrafish and mice (4/11)
- In line with the AlphaFold prediction, we show that Tmem81, Izumo1, and Spaca6 interact in zebrafish sperm and that the human orthologs interact in vitro (5/11)
- We ran all known fertilization factors in zebrafish against 1,400 testis proteins with the help of @86dominik.bsky.social (2/11)
- This screen predicted a conserved sperm complex of Izumo1, Spaca6, and a new related factor, Tmem81, which had been previously uncharacterized in fertilization (3/11)
- [Not loaded yet]
- [Not loaded yet]
- ...members of the @pauligroup.bsky.social (e.g. @johannessuwita.bsky.social, Karin Panser, @claraphan.bsky.social), Alex Schleiffer, @86dominik.bsky.social & our amazing proteomics facility @elisabethroitinger.bsky.social @impvienna.bsky.social @imbavienna.bsky.social, ... (9/11)
