Shicheng Guo

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  Shicheng Guo shihcheng.bsky.social · May 14
  Exploring Menshen antiphage system: Decoded organization and evolution via 6 domain determinants using genomics & protein bioinformatics. Retweet! PMID:40347139, Nucleic Acids Res 2025, @NAR_Open doi.org/10.1093/nar/gkaf357 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

  https://doi.org/10.1093/nar/gkaf357

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  Shicheng Guo shihcheng.bsky.social · May 14
  New findings reveal the MukBEF SMC complex captures DNA by opening entry gates upon ATP binding, while bacteriophage T7's gp5.9 inhibits this process. PMID:40168993, Cell 2025, @Cell cell.com/cell/fulltext/S0092… #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

  https://www.cell.com/cell/fulltext/S0092-8674(25)00259-4

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  Shicheng Guo shihcheng.bsky.social · May 14
  Study: Rilzabrutinib, a BTK inhibitor, shows promise in Phase 2 trial for antihistamine-refractory chronic spontaneous urticaria. PMID:40266575, JAMA Dermatol 2025 doi.org/10.1001/jamadermato… #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

  https://doi.org/10.1001/jamadermatol.2025.0733

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  Shicheng Guo shihcheng.bsky.social · May 12
  Mammalian longevity: 482 longevity-linked proteins, 695 acetylation sites found. PHARAOH tool unveils how acetylation roles differ across 107 species! 🔍🧬 PMID:40263264, Nat Commun 2025, @NatureComms doi.org/10.1038/s41467-025-… #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
  

  The mammalian longevity associated acetylome | Nature Communications

  Despite extensive studies at the genomic, transcriptomic and metabolomic levels, the underlying mechanisms regulating longevity are incompletely understood. Post-translational protein acetylation is suggested to regulate aspects of longevity. To further explore the role of acetylation, we develop the PHARAOH computational tool based on the 100-fold differences in longevity within the mammalian class. Analyzing acetylome and proteome data across 107 mammalian species identifies 482 and 695 significant longevity-associated acetylated lysine residues in mice and humans, respectively. These sites include acetylated lysines in short-lived mammals that are replaced by permanent acetylation or deacetylation mimickers, glutamine or arginine, respectively, in long-lived mammals. Conversely, glutamine or arginine residues in short-lived mammals are replaced by reversibly acetylated lysine in long-lived mammals. Pathway analyses highlight the involvement of mitochondrial translation, cell cycle,

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  Shicheng Guo shihcheng.bsky.social · May 11
  Discover MMEASE 2.0: A groundbreaking workflow enhancing single-cell metabolomics, shifting research focus from bulk to SCM for better insights. PMID:40308213, Nucleic Acids Res 2025, @NAR_Open doi.org/10.1093/nar/gkaf363 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

  https://doi.org/10.1093/nar/gkaf363

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