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Did editors accepted your justification ? (bad experience here).
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Et la bourse de thèse est nettement repassée au dessus du smic sous Sarkozy je crois me rappeler, alors que Fabius n'en avait pas grand chose à faire (malgré quelques manifs de thésards sous ses fenêtres à Bercy)...
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Oui, et je l'annoncerai même quelques heure avant sur mon réseau social "best time to buy !"
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Plutôt en allemand ou tcheque qu'en russe... et c'était quand meme plus impressionnant.
So after 2 months of trump2 you now need a burner phone to enter the US 😭
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Ah ok, merci pour la clarification !
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Je parle de l'alignement avec les positions covid, mais c'est peut etre anecdotique.
C'est du gut feeling ou c'est documenté ?
Neonatal fungi promote lifelong metabolic health through macrophage-dependent β cell development | Science
www.science.org/doi/10.1126/...
Neonatal fungi promote lifelong metabolic health through macrophage-dependent β cell development
Loss of early-life microbial diversity is correlated with diabetes, yet mechanisms by which microbes influence disease remain elusive. We report a critical neonatal window in mice when microbiota disr...
Are you curious about eukaryotic plasmids?
PhD student Fabien Girard with Axel Cournac in the lab explore the positioning of plasmid 2u, one of these rare (known) episomes, in the budding yeast nucleus. The results were surprising.
#plasmids #chromatin #3Dgenome
www.embopress.org/doi/full/10....
Parasitic plasmids are anchored to inactive regions of eukaryotic chromosomes through a nucleosome signal | The EMBO Journal
imageimageThe naturally occurring S. cerevisiae 2µ plasmid is one of few documented cases of eukaryotic plasmids, undergoing equal
distribution between mother and daughter cells during mitosis. Using ...
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What is nice is that this phenomenon is not limited to 2u and yeast species !
Another known parasitic plasmid, Ddp5 in the amoeba Dictyostelium discoideum, also sticks to the silent regions of this genome! This suggests a more generalized phenomena.
We are now trying to clarify the molecular mechanisms at play...
A work with contributions of past and present lab members Agnes Thierry,
@leameneu.bsky.social, Pauline Larrous, and with Sandrine Adiba at ENS for the amoeba cultures.
These contacts do not depend on chromosome structural factors, such as SMC complexes, but on a signal encoded by nucleosomes (apparently located in histone H4 tail), associated with depletion of RNA Pol II.
We used a yeast strain containing a non-transcribed bacterial genome to show that this artificial chromosome titrates the 2u plasmid in the “inactive” compartment
(described recently in Meneu et al
www.science.org/doi/10.1126/... ) (tks Angela Taddei, Myriam Ruault & Antoine Even)
Using dozens of published genomic datasets, and new experiments, we show that this ~6 kb molecule is positioned preferentially in untranscribed regions of the genome, often corresponding to long inactive genes.
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Maybe they should lock him inside so he can count the gold and reopen the vault in 2075.
I have to admit I never thought I'd see the day when a US vice president would warmly support European far right and spit on all democratic principles.
www.theguardian.com/us-news/2025...
JD Vance stuns Munich conference with blistering attack on Europe’s leaders
US vice-president questions whether European values are worth defending as he rails against ‘threat from within’
Two more weeks to apply to join us in Paris !
research.pasteur.fr/en/call/call...
Call for applications 2025 - Creation of new research groups at the Institut Pasteur - Research
The Institut Pasteur launches an international call to recruit new junior research group leaders in the application of cutting-edge transdisciplinary approaches to the exploration of host-microbe, tis...
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🖐️ thanks!
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Our latest work: how can compartmentalization emerge in a eukaryotic genome lacking canonical heterochromatin?
By investigating bacterial genomes put in yeast, we show that the presence or absence of transcription is sufficient!
#chromatin #3Dgenome #generegulation
www.science.org/doi/10.1126/...
👇
Sequence-dependent activity and compartmentalization of foreign DNA in a eukaryotic nucleus
In eukaryotes, DNA-associated protein complexes coevolve with genomic sequences to orchestrate chromatin folding. We investigate the relationship between DNA sequence and the spontaneous loading and a...
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All these results and much more can be found in our paper, a massive work led by
@leameneu.bsky.social,
@christophechapard.bsky.social, and Jacques Serizay who generated all the beautiful analyses. Thanks to all the contributors, esp.
@chromozz.bsky.social and Alex Westbrook for the deep-learning!
See also accompanying perspective by
@gfudenberg.bsky.social and
@vram142.bsky.social :
Relating DNA sequence, organization, and function | Science
www.science.org/doi/10.1126/...Deep learning models (
@chromozz.bsky.social) trained only on yeast chromosomes predict nucleosome positioning, RNA Poll II and cohesin tracks along foreign DNA, based on the sequence alone. This implies that the behavior of any DNA in a host cell follows deterministic sequence-based rules.
This result suggests that simple sequence-dependent features could have contributed to the emergence of bipartite compartmentalization of genomes during evolution, either by sequestering inactive genetic material or by facilitating the functional integration of active sequences.
Sequences close to the yeast GC are highly transcribed, somehow following the orientation of prokaryotic genes, and mix with yeast chromosomes.
In contrast, a rich AT bacterial genome is not transcribed and forms a globule at the nuclear periphery, independently of SIR heterochromatin formation...
Dispersed over several chromosomes, this inactive compartment is maintained until mitosis when cohesins compact all chromosomes similarly.
Reducing transcription eliminates compartmentalization, with all yeast chromosomes now resembling the bacterial chromosome...
Using MNAse, ChIP, ATAC, CRAC and RNA-seq, Hi-C and imaging, we characterized the composition, activity and folding of bacterial genomes of varying sequence composition introduced as supernumerary chromosomes into budding yeast. Depending on their GC%, their fate was surprisingly different.
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Innovation dans la fabrique des sacs a main et des valises, hein.
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Toutafé
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Toutes les sections n'en ont pas d'ailleurs. Pour avoir siégé dans les deux types je confirme que le clarté de l'info dans le dossier est primordiale dans un cas comme dans l'autre...
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Et c'est pas faute de le répéter...
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On peut lire "les mains du miracle" de Kessel, d'ailleurs pour la version tres romancee de Kersten... mais pour les révélations sur le fait que les bus ont d'abord servi à déplacer des prisonniers vers d'autres camps pour regrouper des "nordiques" sur un site il faut lire les historiens...
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Non, Nantes n’est pas une ville plus dangereuse que Bogota
Ce classement, repris par certains médias, n’est basé que sur les votes de quelques internautes
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C'est aussi intéressant en demandant de critiquer certains aspects entre les lignes... c'est pas subtil et je me demande si ça reflète des vacheries balancées dans des vrais rapports jamais vus dans mon domaine !
Institut Pasteur 2025 call for group leader ! A fantastic place to do science in a great city.
Have a look, repost and don't hesitate to reach out for more info...
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🖐️ ? thanks
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La Mouette à l'Odéon
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A step that often follows awareness of strains, individuals and genetic redundancy :-)
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And that's before Gaetz even started.
The Onion's purchase of Infowars (if true) is the second highlight of my week after the long awaited migration of thousands of academics to Bsky...
Interested in chromatin architecture?
Checkout our new method - PCP - that can map genome organization as multi-way interactions as well as nucleosome footprint and nucleosome spacing at very high resolution.
www.biorxiv.org/content/10.1...
Chromatin architecture mapping by multiplex proximity tagging
Chromatin plays a pivotal role in genome expression, maintenance, and replication. To better understand chromatin organization, we developed a novel proximity-tagging method which assigns unique DNA b...
Very nice Axel ! Congratulations !
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Et les CID ? Ça reste en place ?
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Starting with cops (all models) apologising and fist bumping homeless people on the bank of the Seine because they have to evict them temporarily sets up the movie to be a cult one right away...
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C'est pour moi la phrase la plus fumée de toute la séquence, c'est pas faute pourtant d'avoir entendu l'histoire du vaccin ARN (ou d'autres techno comme crispr)...
