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- The 'personal fat threshold' concept explains how #T2D can potentially be reversed both at higher and 'normal' BMI #DiabetesResearch #Endocrinology #MedSky #Review
- Myosin (the most abundant skeletal muscle protein) becomes super-relaxed and energy-efficient in #T2D #DiabetesResearch #Endocrinology #MedSky
- The most abundant skeletal muscle protein (myosin) becomes super-relaxed and energy-efficient in type 2 diabetes mellitus #T2D #DiabetesResearch link.springer.com/article/10.1... 🔓
- People with #MASLD can progress to cirrhosis & hepatocellular carcinoma & are at increased risk of developing type 2 #diabetes, #cardiovascular disease, chronic #kidney disease, & extrahepatic #cancers www.thelancet.com/journals/lan... #T2D #CVD #CKD #obesity #OpenAccess #MedSky #EndoSky #LiverSky
- The most abundant skeletal muscle protein (myosin) becomes super-relaxed and energy-efficient in type 2 diabetes mellitus #T2D #DiabetesResearch link.springer.com/article/10.1... 🔓
- Elegant studies in mice link aspartame to accelerated #atherosclerosis through enhanced #insulin action. www.cell.com/cell-metabol... Yet in humans #T2D insulin Rx in the ORIGIN trial was not linked to increased rates of #heartdisease www.nejm.org/doi/full/10....
- Keeping an eye of the safety of semaglutide #weightloss #T2D #obesity An update on NAION www.nature.com/articles/s41...
- youtu.be/TZ67Wsgs5AE?... My most recent grocery haul for glp-1 friendly higher protein lower carb food choices. 82 lbs lost eating these foods for 15 months..about 60 more lbs to go! #mounjaro #t2d #over60 #groceryhaul
- The relationship between shrunken pore syndrome increased mortality in people with #T2D #DiabetesResearch #KidneyResearch #Endocrinology #MedSky
- Shrunken pore syndrome (eGFRcyst/eGFRcreat <0.60) is associated with increased mortality in people with T2D, including those with normal eGFRcreat and ACR, confirming the prognostic value of measuring cystatin- as well as creatinine-based eGFR link.springer.com/article/10.1... 🔓
- Interesting data on #Epigenetic pathways in diabetic neuropathy #DiabetesResearch #T2D #Neuropathy #Endocrinology #MedSky
- DNA methylation at loci including CHMP6, CACNA1B and PKNOX1 was associated with 28 year neuropathy incidence in the Pittsburgh Epidemiology of Diabetes Complications study type 1 diabetes cohort #T1D #DiabetesResearch link.springer.com/article/10.1...
- The rising prevalence of people with a high #BMI, increasing rates of type 2 #diabetes, and a greater #fall risk in people with #obesity and type 2 diabetes has contributed to a substantial rise in #fractures thelancet.com/journals/lan... #T2D #osteoporosis #BoneHealth #MedSky #EndoSky #RheumSky
- Study looking at possible mechanisms for interactions between #T2D and #Alzheimer's disease #DiabetesResearch #Endocrinology #MedSky
- Alterations in cerebral perfusion and substrate metabolism in type 2 diabetes: interactions with APOE-ε4 link.springer.com/article/10.1... 🔓
- The OG GLP-1 medicine twice daily Exenatide from the salivary gland of Heloderma Suspectum to the clinic for type 2 #diabetes Approved by the @US_FDA April 28 2005. Happy anniversary to the groundbreaking molecule that launched a new class of transformative medicines #T2D
- A missense variant in ABCC8 gene may be responsible for increase in birthweight #GWAS #Genetics #DoHAD #T2D #DiabetesResearch #MedSky
- These authors used winsorisation when performing #GWAS of birthweight and discovered missense variant in the ABCC8 gene estimated to be responsible for a 170g increase in birthweight amongst carriers #DoHAD #T2D link.springer.com/article/10.1... 🔓
- These authors used winsorisation when performing #GWAS of birthweight and discovered missense variant in the ABCC8 gene estimated to be responsible for a 170g increase in birthweight amongst carriers #DoHAD #T2D link.springer.com/article/10.1... 🔓
- Post hoc analysis of ONWARDS 1–5 trial data indicating no additional increase in #hypoglycaemia risk attributed to #PhysicalActivity with once-weekly #insulin icodec vs once-daily basal insulins in #T2D #DiabetesResearch #Endocrinology #MedSky
- Post hoc analysis of ONWARDS 1–5 trials suggests no additional increase in #PhysicalActivity-attributed #hypoglycaemia risk with once-weekly #insulin icodec vs once-daily basal insulins in #T2D. link.springer.com/article/10.1... 🔓
- Explore the clinical potential of type 2 #diabetes-related PGSs for risk prediction and screening of #T2D and its comorbidities and risk stratification, with attention to their global applicability, in this #EdsChoice review from @diabetologiajnl.bsky.social 👉 buff.ly/ZFrNasA #DiabetesSky #MedSky
- A look at the renal biology of people with eGFR inferred “shrunken pore syndrome” #T2D @diabetologiajnl.bsky.social link.springer.com/article/10.1...
- Post hoc analysis of ONWARDS 1–5 trials suggests no additional increase in #PhysicalActivity-attributed #hypoglycaemia risk with once-weekly #insulin icodec vs once-daily basal insulins in #T2D. link.springer.com/article/10.1... 🔓
- New data looking at early microvascular changes in the retina among people with #T2D and novel diabetes subtypes #DiabetesResearch #Endocrinology #PrecisionMedicine #MedSky
- #OCTA detects early microvascular changes in the retina (#T2DM, especially in insulin-deficient and mild obesity-related) and the choroid (#T1DM, T2DM) within the first year—without signs of diabetic retinal neurodegeneration. #Diabetes link.springer.com/article/10.1... 🔓
- Interesting data suggesting pathways whereby gut barrier damage exacerbates endotoxaemia and systemic inflammation, via neutrophil extracellular traps, leading to progression of diabetic retinopathy in #T2D #DiabetesResearch #Endocrinology #MedSky
- Up front & free to read in our April issue #editorspicks: Intestinal neutrophil extracellular traps promote gut barrier damage exacerbating endotoxaemia, systemic inflammation and progression of diabetic retinopathy in type 2 diabetes link.springer.com/article/10.1...
- Proud to see the work of 3x EFSD grant recipient, Dr Rashmi Prasad B, supported by #EFSD/@elilillyandcompany.bsky.social. The review explores how polygenic scores can shape #T2D prediction & understanding, while calling for better equity in diverse populations. 🔗👉 link.springer.com/article/10.1...
- Glycaemic control in mice with insulin resistance and #T2D ameliorated by treatment with HEXA-FC protein #DiabetesResearch #Endocrinology
- Chronic HEXA–FC treatment improves glycaemic control in mice with insulin resistance and type 2 #diabetes by increasing muscle glucose disposal. #T2D #DiabetesResearch #InsulinResistance link.springer.com/article/10.1... 🔓
- Chronic HEXA–FC treatment improves glycaemic control in mice with insulin resistance and type 2 #diabetes by increasing muscle glucose disposal. #T2D #DiabetesResearch #InsulinResistance link.springer.com/article/10.1... 🔓
- Insights into the role of CD47 in regulating pancreatic islet dysfunction #Islets #T2D #DiabetesResearch #Endocrinology #MedSky
- In this study, Kale et al demonstrate that CD47 is upregulated in islets in response to exogenous stressors, providing insights into the role of CD47 as a regulator of islet dysfunction link.springer.com/article/10.1... 🔓
- ❗ New Journal Club session online ❗️ Early Career Academy member Domenico Tricò presents his recently published study in @diabetologiajnl.bsky.social, exploring mechanisms & clinical impact of postprandial hypoglycaemia after gastric bypass in #t2d. 📺 Watch now youtu.be/PPkZP51dQAo #earlycareer
- New mouse data eluicidating the link between the immune system and #DiabeticRetinopathy, with potential for drug targets and biomerkers #T1D #T2D #DiabetesResearch #Endocrinology #MedSky
- Study shows that low-dose IL 2 reduces vascular injury in mice with #DiabeticRetinopathy by balancing Tregs and CD8+ T cells. #T1D #T2D link.springer.com/article/10.1... 🔓
- Study shows that low-dose IL 2 reduces vascular injury in mice with #DiabeticRetinopathy by balancing Tregs and CD8+ T cells. #T1D #T2D link.springer.com/article/10.1... 🔓
- A retrospective study looking at #T2D remission following weight loss and its effect on #diabetes complications #DiabetesResearch #Endocrinology #MedSky
- A retrospective study on early weight loss and long-term glycaemic trajectory after diagnosis of #T2D shows that remission, more than weight loss, affects future occurrence of chronic complications. link.springer.com/article/10.1... 🔓
- A retrospective study on early weight loss and long-term glycaemic trajectory after diagnosis of #T2D shows that remission, more than weight loss, affects future occurrence of chronic complications. link.springer.com/article/10.1... 🔓
- Want to know more about the genetic link between #T2D and #CVD? Check out this review synthesising the latest genetic evidence and shedding light on the shared genes and biological pathways underlying these complex diseases link.springer.com/article/10.1... 🔓
- Want to know more about the genetic link between #T2D and #CVD? Check out this review synthesising the latest genetic evidence and shedding light on the shared genes and biological pathways underlying these complex diseases link.springer.com/article/10.1... 🔓
