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- How are genes switched on? 🦠 In the simplest organisms, genes were activated by switches nearby 🐒 Animals later evolved distal regulation—folding DNA so distant regions could switch genes on, enabling complex cells without new genes But... when did distal regulation begin? ⬇️ #GeneRegulation #CNAG
- Our latest work: how can compartmentalization emerge in a eukaryotic genome lacking canonical heterochromatin? By investigating bacterial genomes put in yeast, we show that the presence or absence of transcription is sufficient! #chromatin #3Dgenome #generegulation www.science.org/doi/10.1126/... 👇
- Finally out! We present EXTRA-seq, a new EXTended Reporter Assay to quantify endogenous enhancer-promoter communication at kb scale! www.biorxiv.org/content/10.1... A 🧵about what it can do: #SynBio #DeepLearning #GeneRegulation
