- The push for psychedelic therapy trials to address unblinding is good. But my impression is that the large majority of all mental health interventions rely on trials with poor blinding. Should we not recommend psychotherapy, exercise, all psychiatric drugs with noticeable effects, etc?
- It would probably be helpful to evaluate all these interventions using more than symptom rating scales. What’s the latest data on psychedelics reducing suicide attempts for example?
- I think there haven't been nearly enough participants to get significant data on attempts (at least for MDMA). MDMA trials showed really good results on ideation, but that's self report.
- Ok, ideation also decreases with SSRIs, but suicide attempts tend not to. I'm curious to see where psychedelics rank here. I'm always not so sure what role unblinding plays in such "hard" outcomes.May 15, 2025 19:58