Life Science Editors: Important additional information here that would have been useful in the abstract is that ZHX2 is a transcriptional repressor (of the zinc finger and homeobox family).

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Life Science Editors lifescienceeditors.bsky.social · Apr 4
Our team of former journal editors know why papers get published. So, why did the Mol Cell editors publish this?👇 We know hypoxia causes cancer. But here's a new mechanism - phase separation. Hypoxia causes phase separation of ZHX2, altering it's function so it activates metastatic genes. 👍
- Molecular Cell handle.invalid · Apr 3
  Online Now: Hypoxia-induced phase separation of ZHX2 alters chromatin looping to drive cancer metastasis Online now:
  Hypoxia-induced phase separation of ZHX2 alters chromatin looping to drive cancer metastasis
  
  Gao et al. reveal a type of hypoxia-specific phase separation mediated by ZHX2 IDR, which serves as a scaffold for recruiting CTCF and active transcriptional regulators (e.g., RNA Pol II-S5P, MED1, and BRD4), thus reprogramming chromatin looping to drive oncogene transcription and cancer metastasis.
  
  dlvr.it
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Life Science Editors lifescienceeditors.bsky.social
Important additional information here that would have been useful in the abstract is that ZHX2 is a transcriptional repressor (of the zinc finger and homeobox family).
Apr 4, 2025 07:12
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