JCI insight
High-quality, topflight, and clinically impactful basic and translational research representative of all biomedical specialties and physician-scientists: insight.jci.org
- ASCI member Goutham Narla et al. highlight Aβ as a predisposition gene in breast cancer development & potentially additional cancers:
- Study by Yin, Kurts, et al. shows that metabolic cages are more stressful for mice than traditional cages & thus may influence outcomes in kidney injury research: buff.ly/00Yz2bS
- ASCI member Coffey et al. establish DPEP1’s importance in maintaining microsatellite stable colorectal cancer, and its ability to shape the tumor microenvironment: buff.ly/3jk29QP
- Woodfold Bryant et al. establish a link between rhinovirus, an important trigger of acute wheeze, and aberrant airway T-cell dynamics in kids with treatment-refractory recurrent wheeze: buff.ly/bheRSUU
- Cover article by Pei-Suen Tsou, David Fox and team reveals that inflammatory mediator soluble CD13 (sCD13) is an immunothrombosis trigger in SARS-CoV-2 patients: buff.ly/O8Oh3yd
- Authors' mouse model of Prader-Willi syndrome with Necdin and Magel2 deletion showed neonatal lethality, behavioral, metabolic & neuroanatomical alterations that closely parallel clinical features of PWS: buff.ly/fYIPbGo
- Hao & Li et al reveal flaws in ACTH test for diagnosing adrenal insufficiency in sepsis – underscoring a need for a new diagnosis & reevaluation of glucocorticoid therapy: buff.ly/4DmeHuB
- @mickymarinelli.bsky.social and team designed and developed a PKCε small molecule inhibitor that reduces cancer chemotherapy-induced pain and prevents & reverses opioid withdrawal pain: insight.jci.org/articles/vie...
- Bing Ma, Jonathan S. Bromberg, and team build a foundation for optimizing long-term rapamycin regimens, potentially enhancing graft survival and extending applications beyond transplantation: buff.ly/jUXK3bm
- Giles et al. show the beneficial effects of bazedoxifene+conjugated estrogens on metabolic health & also reduced the markers of breast cancer risk in a perimenopause and obesity rat model: buff.ly/8mlcs6l
- Rhon-Calderon et al. show that IVF causes morphological and molecular defects in the male reproductive system & that adverse outcomes are transmitted to the next generation: buff.ly/PrHov6H
- Haag et al. discover a novel metabolic signature to diagnose lean MASLD early, potentially paving the way to explore new therapeutic interventions for this clinically underdiagnosed spectrum of liver disease: buff.ly/DtltnAD
- 2023 ASCI Emerging-Generation recipient @rramonell.bsky.social identify a novel target to manage treatment-refractory asthma by describing a significant association of airway CD8+ TEMRA cells with asthma duration: buff.ly/gmsfzyQ
- Cheng Ai et al. investigate the effects and therapeutic potential of VA supplementation in Leber hereditary optic neuropathy--an inherited form of vision loss–their findings may impact its precision diagnosis and treatment: buff.ly/KXzfDaY
- @tfujik.bsky.social and team generate a novel mouse model, Sf-1-Flp, and show its functional utility in addressing previously unapproachable questions about the ventromedial hypothalamic nucleus (VMH): buff.ly/GhdFw8U
- Authors of a randomized-control trial show that giving the elderly high doses of influenza vaccine revealed immune responses similar to younger adults receiving the standard dose: buff.ly/MMjwg7W
- Cover article by Zhang and Jin shows that disrupting the CK2-PIAS1-SPOP signaling axis could increase the efficacy of PARP inhibitors, a targeted therapy, against prostate cancer: buff.ly/JXTgtUi
- Brown et al. identify that ZNF469—a zinc finger protein—regulates how scar tissue forms in the liver in response to fat accumulation: buff.ly/uO0e5xI
- Fong ASCI et al. show that JAK inhibition administered sequentially enhances anti-tumor immunity after combined anti-PD-1 and anti-CTLA4 therapy in pre-clinical prostate cancer study: buff.ly/xUtLG3a
- Shi Yong Neo et al. show that atypical memory B cells can be immunosuppressive & found within peripheral blood and tumor microenvironment of hepatocellular carcinoma patients: buff.ly/5X8otAX
- Urs Christen & team prove, for the first time, that the XCL1 / XCR1 chemokine axis is essential for the development of T1D & build a basis for a subsequent therapeutic intervention: buff.ly/R5sJiPO
- Authors highlight a natural immunity signature of chlamydia trachomatis by IDing key T cell subsets that correlate with reduced re-infection risk in women with high exposure:
- In JCI insight: Perspective by Koretzky provides a historical review of the physician-scientist career path and offers seven recommendations to promote its importance & reinvigorate its future, at all its stages:
- Plaza-Jennings et al. identify key areas for improved partnership between pre-health advisors and MD/PhD Programs to build a robust physician-scientist pipeline:
- Perspective by ASCI members Williams and Rhee documents the genesis of the ASCI/AAIM/BWF Physician-Scientist Pathways Annual Workshop & offers plans to pave and formalize the career path for future physician-scientists:
- Lawrence F. Brass, Maurizio Tomaiuolo, Aislinn Wallace, and Myles H. Akabas show that MD-PhD program applicant metrics do not predict short or long-term physician-scientist performance: buff.ly/KKFcCHV Video Abstract:
- Our current issue's special collection of Physician-Scientist Development articles includes an editorial by Editor in chief @eickelbergmd.bsky.social & is paired with a cover collage of children's drawings illustrating what a 'physician-scientist' means to them: buff.ly/kQ4fmrg
- Lynch syndrome has up to 60% lifetime risk of endometrial cancer & Bowen et al. are first to identify that mitochondrial dysfunction via MSH2 loss is a mechanism for LS-EC – results bring important implications for cancer interception or therapy: buff.ly/qkDYXMQ
- ASCI member Michael Levine et al. show that both biallelic and monoallelic variants of FAM111A can lead to rare genetic disorder KCS type 2 and OCS & demonstrate that increased FAM111A function adversely affects immune function: buff.ly/63i05L8
- Benjamin Sasko et al. develop a novel, validated, fluorometric biochemical cell-free assay & show first evidence of a strong association of oxidized HDL with the occurrence of acute coronary syndrome–a new approach may applied to future large-scale trials: buff.ly/M5mFY0L
- Bo Jiang, Pengwei Ren, Changshun He et al. demonstrate that the short-term disruption of TGFβ signaling in adult mice renders the aorta vulnerable to hypertension-induced dissection: buff.ly/5ZT5zw4
- Authors confirm that the clinical course of the disease in genotype-negative patients with MEN1 is distinct from those with genotype-positive MEN1-the latter may not benefit from annual surveillance & propose a novel weighted, diagnostic scoring system: buff.ly/0WxT7sX
- Lynch Syndrome (LS) carries a10-20x lifetime risk for colorectal cancer (CRC)-authors show EZH2 inhibition modulates the immune landscape in a mouse model of LS-CRC & provide promising insight for launching a phase 1 trial: buff.ly/jDdqbjY
- Jazmin Calyeca et al. identify a fibroblast subset as a signaling hub in airway repair, uncover their heterogeneity and distinct spatial distribution, and explain their specific roles in airway reconstruction. buff.ly/w6vovvF
- In trial of IL-7 in patients with severe respiratory failure authors challenge conventional wisdom re: COVID-19's pathophysiology & demonstrate that IL-7 may have efficacy in future pandemic respiratory viral infections: buff.ly/IWIGSyU
- Metabolomic study by Afaf Saliba et al. unveils a toxic tryptophan metabolite that links kidney decline to toxic brain milieu. buff.ly/Vyg8ZyD In the attached video clip, Afaf Saliba & Kumar Sharma explain their research. Full video: buff.ly/0Ns2PUL
- ASCI member Julie K. Schwarz et al. are 1st to suggest that fusobacterium in the post-menopausal vaginal microbiome may correlate w/ treatment response in locally advanced cervical cancer & provide proof-of-concept for future study: buff.ly/LG1JT1t
- In our cover, Waich et al. record progress for early-onset O2HE Syndrome–their analysis of the UNC45A c.710T>C 37 missense variant uncovered its pathogenic mechanisms & recessive 46 characteristics and may aid in the development of targeted therapies: buff.ly/sU0qlNx
- Burns, Wilson et al. demonstrate that the neutrophils present in menstrual effluent are necessary for attachment and survival of endometriosis lesions. buff.ly/ofjiHG7
- Mark P. de Caestecker and team show repair after reversal of urinary obstruction leads to permanent changes in the structure and function of all major cellular compartments in the renal medulla. buff.ly/vQDf075
- Study by de Silva, Joshi, and Kumar demonstrates a critical role of Fn14-meditated signaling in satellite cells for skeletal muscle regeneration in response to injury and in an animal model of Duchenne muscular dystrophy. buff.ly/sUxzSxw
- A genetic variant in Map2k6 provides significant protection from aortic rupture in vascular Ehlers-Danlos Syndrome (vEDS) in a mouse model–pharmacologic strategies aimed at mimicking the effect may improve prevention: buff.ly/zbTB6DR
- Puneet Opal and team show that neurofilaments accumulate and dually disrupt the process of autophagy in neurons when gigaxonin function is compromised--contributing to the pathogenesis of other neurodegenerative diseases with neurofilament accumulations. buff.ly/r4PXEnt
- Highly mentioned article: Using an AAV-delivered adenine base editor, Ukaji et al. corrected a mutation in GJB2 gene—restoring key cell connections in the ear. This research could lead to future treatments for GJB2-related deafness & skin diseases! buff.ly/4a785IY
- YPSA recipient Abby Green, Davenport, et al. found that APOBEC3A (A3A), an innate immune enzyme involved in virus restriction, acts abnormally in ovarian cancer cells to promote metastasis. buff.ly/MgAgU9b
- @drjriveracorrea.bsky.social & ASCI member Alessandra Pernis find that ROCK1, a serine/threonine kinase, plays a critical role in protecting B cells when exposed to damaging and stressful environments. buff.ly/XLYKYW3
- First of its kind, comprehensive study in aging type 1 diabetes individuals by Shah et al. indicates that T1D cognitive decline differs from T2D–and improving visual acuity could be a novel preventive measure: buff.ly/rJG7nHV
- First-in-human Phase I study by ASCI member Michael Caligiuri and team provides an important step forward in using sIL15_TRACK NK cells to treat advanced solid tumors: buff.ly/3ZlYqcj
- On our Cover: Kolachala & Kugathasan et al. @emorydeptofmed.bsky.social use a first-in-kind, multi-omic approach to uncover cell type-specific shifts within the Crohn’s disease tissue microenvironment- verifying the molecular and cellular networks underlying active CD: buff.ly/qb3GGCH
- Daniela Weiskopf and team reveal that 2 prior dengue infections are needed for Dengue-specific CD8+ T cells to protect against a subsequent infection–a tropical disease causes ~400 million infections/year wo effective vaccines: buff.ly/Tdbs13O
