Conor Browne: 4. This is also why cutting funding to programmes that provide antiretroviral therapy to people with HIV is not only a priori morally wrong, but also short-sighted - by removing access to ART therapy these patients are more likely to develop chronic SARS-CoV-2 infections. /end

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Conor Browne brownecfm.bsky.social · Apr 24
1. This adds weight to a point I've been making for years, namely, that the important differential at the population level between now and the Spanish Flu of 1918-1920 is the considerably higher percentage of the global population who are immunocompromised. www.biorxiv.org/content/10.1...
Antibody escape drives emergence of diverse spike haplotypes resembling variants of concern in persistent SARS-CoV-2 infections

Evolution of SARS-CoV-2 in long-term persistent infections is hypothesised to be a major source of variants of concern (VOC). However, the linkage of intra-host variants into haplotypes that reflect v...

biorxiv.org

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Conor Browne brownecfm.bsky.social · Apr 24
2. People who were immunocompromised as a result of primary immunodeficiencies didn't live long in 1918, because antibiotic therapy didn't exist. Likewise, medication that causes immunosuppression didn't exist either.

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Conor Browne brownecfm.bsky.social · Apr 24
3. Additionally, HIV / AIDS didn't exist in 1918. All of these factors explain why there are vastly more immunocompromised people now compared to then. As such, the global immune landscape is much more conducive to viral mutation in this pandemic than it was in 1918 - 1920.

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Conor Browne brownecfm.bsky.social
4. This is also why cutting funding to programmes that provide antiretroviral therapy to people with HIV is not only a priori morally wrong, but also short-sighted - by removing access to ART therapy these patients are more likely to develop chronic SARS-CoV-2 infections. /end
Apr 24, 2025 09:47
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Antibody escape drives emergence of diverse spike haplotypes resembling variants of concern in persistent SARS-CoV-2 infections