As with many things, the final breakdown of complex systems, may not be where obvious activity/damage is. It seems obvious that autoimmune loss of
#cns #myelin in
#MS is due to an attack on myelin-think again, perhaps it’s against a less obvious but critical system:
#astrocytes
#neuroskyence #gliaExcited to share our latest paper!
We argue that in MS, the primary immune attack isn’t on myelin or myelinated axons — but on the ion & water homeostasis machinery in astrocyte endfeet.
A short thread on this new perspective
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