Antibiotic Steward 🅱️C🆔🅿️🌟
Stay up-to-date in Infectious Diseases, Clinical Pharmacist, Antibiotics, #IDTwitter t✨p influencer #interstellar #dune
🌹❤️Misk #idsky #medsky #AMSsky #idxposts
Bassam Ghanem,PharmD MS BCPS BCIDP
- A brilliant title that flips the classic quote to reflect how the practice of medicine evolves. This article pushes back against IV dogma in bone & joint infections, spotlighting the solid evidence for oral therapy. A much-needed shift—one I fully stand behind #idsky
- 🆕💫Standing on the Shoulders of Imperfect Humans: from IV dogma to oral antibiotic therapy for bone and joints infections #idsky www.sciencedirect.com/science/arti...
- So glad you like😊 Backstory- @gurujosh.bsky.social suggested a series celebrating past giants/landmark papers Then we learned CMI was by chance doing something similar:'Standing on the Shoulders of Giants' So w/ Leonard's OK, we decided to turn it on its head #IDSky www.cmi-comms.com/article/S295...
- I didn't know it's a series , I'm so excited!
- This one is really nice-and hits close to home bc Waldvogel is a local legend here in🇨🇭, but they managed it so well. We have some really nice ones in the pipeline, including one from @dremilymcd.bsky.social & @drtoddlee.bsky.social that I think you'd love but is going through peer review now #IDSky
- Can't wait! Thanks
- Practice changer RCT? No difference in perforation risk if surgery <24h. Slightly lower SSI (1.6% vs 3.2%), but not statistically significant. Supports a more selective, stewardship-friendly approach—especially with timely surgery access #IDsky #EMIMCC
- 🔥🆕PERFECT RCT Preoperatively started antibiotic treatment did not decrease the risk of appendiceal perforation when appendectomy was performed within 24h in adult patients with presumed uncomplicated acute appendicitis. #IDsky A new standard of care? jamanetwork.com/journals/jam...
- 🆕💫Standing on the Shoulders of Imperfect Humans: from IV dogma to oral antibiotic therapy for bone and joints infections #idsky www.sciencedirect.com/science/arti...
- Despite its established role in PJI,the use of rifampin remains subject to debate, primarily due to inconsistencies in literature regarding clinical efficacy,timing of initiation,choice of combination agent & variability in outcomes across infection types #idsky www.sciencedirect.com/science/arti...
- 🔥🆕PERFECT RCT Preoperatively started antibiotic treatment did not decrease the risk of appendiceal perforation when appendectomy was performed within 24h in adult patients with presumed uncomplicated acute appendicitis. #IDsky A new standard of care? jamanetwork.com/journals/jam...
- 🆕💫The MEFIER Score - A Risk Score to Stratify Infective Endocarditis in Patients with Enterococcus faecalis bacteremia based on an 11-year territory-wide cohort AUROC of 0.79 (95%CI 0.72-0.88), and a NPV of 0.98 (95%CI 0.97-0.99) #idsky #IEWiki academic.oup.com/ofid/advance...
- 🆕💫 Systematic Review and Meta-Analysis 30 observational studies( SNAP & CloCeBa not included) N: 3869 Cefazolin versus Antistaphylococcal Penicillins for the Treatment of MSSA Bacteremia #idsky www.clinicalmicrobiologyandinfection.com/article/S119...
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- I suspect the issue stemmed from the in vitro inoculum effect of cefazolin. Hopefully, SNAP and its substudies will finally put this theory to rest #idsky
- This will head off the 'but you only used (flu)cloxacillin in SNAP' crowd.
- The results of this meta-analysis suggest that it would be reasonable to extrapolate the findings of SNAP and CloCeBa to the other antistaphylococcal penicillins (i.e., nafcillin and oxacillin) #idsky
